UJI AKTIVITAS ANTIDEPRESAN ISOMIRISTISIN TERHADAP IMMOBILITY TIME MENCIT PUTIH JANTAN (MUS MUSCULUS)

Isomyristicin results from myristicin isomerization and is reported to have the same biological activity as myristicin, an antidepressant. Myristicin at a specific dose causes toxicity, so it necessary study isomyristicin, which estimated myristicin. However, there has been no test related isomyristicin having antidepressant activity. Therefore, this aimed determine optimum of decrease immobility time male white mice (Mus musculus). This used 30 divided into six groups: positive control, negative normal 1.5 mg/Kg BW, 3 6 BW mice. The method measure Forced Swimming Test (FST) Tail Suspension (TST) induce depression. To analyze normality data using Shapiro Wilk one-way ANOVA significant difference in data. result showed all doses ability antidepressant, optimal was 1,5 mg/kg with 82 % percentage proved by post hoc sig. p (<0,05).